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Phagocytosis of Bioactive Microspheres

Research Center for Medical Polymers and Biomaterials Kyoto University 53 Kawahara-cho, Shogoirc, Sakyo-ku, Kyoto 606, JAPAN

Y. Tabata

Research Center for Medical Polymers and Biomaterials Kyoto University 53 Kawahara-cho, Shogoirc, Sakyo-ku, Kyoto 606, JAPAN

The influence of several proteins on the uptake of microspheres was investigated using mouse peritoneal macrophages. Thioglycollate-stimulated macrophages were cultivated for 3 h with protein-grafted and protein-coated cellulose microspheres smaller than 2 µm in the presence and the absence of serum. Bovine serum albumin reduced the phagocytosis of microspheres, while y-globulin, human fibronectin, bovine tuftsin, and gelatin enhanced the phagocytosis. This trend was not influenced substantially by the presence of serum and the mode of surface binding of the proteins; that is, covalent grafting or physical adsorption (coating). However, in the case of gelatin binding, phagocytosis was greatly enhanced by the presence of serum as compared with the other proteins.

Journal of Bioactive and Compatible Polymers, Vol. 1, No. 1, 32-46 (1986)
DOI: 10.1177/088391158600100104


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