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Journal of Bioactive and Compatible Polymers
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The Activity of Complement in the Presence of N-(2-hydroxypropyl)methacrylamide Copolymers

J. Simecková

Institute of Microbiology Czechoslovak Academy of Sciences 142 20 Prague 4, CZECHOSLOVAKIA

B. Ríhová

Institute of Microbiology Czechoslovak Academy of Sciences 142 20 Prague 4, CZECHOSLOVAKIA

D. Plocová

Institute of Macromolecular Chemistry Czechoslovak Academy of Sciences 162 06 Prague 6, CZECHOSLOVAKIA

J. Kopecek

Institute of Macromolecular Chemistry Czechoslovak Academy of Sciences 162 06 Prague 6, CZECHOSLOVAKIA

This study indicates that N-(2-hydroxypropyl)methacrylamide homopolymers and copolymers containing oligopeptide sequences terminated in carboxylic acid groups, amine groups, aromatic units, or puromycin have no prominent effect on the porcine complement system in vitro. Inhibition of both pathways of the complement system occurred at concentrations highly exceeding the dose suitable for therapeutic purposes.

Journal of Bioactive and Compatible Polymers, Vol. 1, No. 1, 20-31 (1986)
DOI: 10.1177/088391158600100103
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